Preclinical research and development of a herbal antipyretic drug based on leaves of Ceiba pentandra (Malvaceae)

Background: Faced with the limits of synthetic antipyretic substances, in particular their involvement in the occurrence of numerous and often serious adverse effects; the challenge is in search of new antipyretics especially from the African traditional pharmacopoeia. The objective of this study was to evaluate the antipyretic activity of an aqueous extract and a formulation of Ceiba pentandra, with a view to designing an herbal antipyretic drug.

Methods: Trials of formulation of an antipyretic syrup with leaves extract of Ceiba pentandra were carried out. The antipyretic activity was investigated by the bewer's yeast induced pyrexia. Physicochemical and microbiological stability tests were carried out on the syrup.

Results: It was found with the extract an antipyretic activity at doses of 125 mg/kg and 150 mg/kg. The effect was greater for the 125 mg/kg dose with inhibition percentages ranging from 27.58% to 71.25%. This antipyretic activity was early (from 30 minutes) and was preserved during the four hours of the experiment. The syrup dosed at 125 mg/kg gave an activity similar to that of the extract by significantly reducing the hyperthermia in the rats. Regarding the stability tests, the syrup remained stable both physico-chemically and microbiologically throughout the study period (28 days) both when exposed to low temperature (5 °±3 ° C) and at high temperature (40°±2° C).

Conclusions: Ceiba pentandra leaves have antipyretic activity and could be used for the development of an herbal antipyretic drug.

Updated:	30 July 2022 05:32:03
License:	Attribution-ShareAlike
Download:	IJBCP-4451 O.pdf
Keywords:	Ceiba pentandra, Antipyretic

Electrolyte disorders in a young female following short-term omeprazole therapy

A 29 years old female presented to us in the metabolic clinic of the University of Port Harcourt Teaching Hospital (UPTH) on account of a week history of easy fatigability, weakness, and lower extremity muscle cramps associated with numbness and tingling sensation in the peri-oral area, fingers and toes. Two weeks prior to the onset of her presenting symptoms, she had visited a local pharmaceutical shop on account of a distressing epigastric discomfort and was subsequently placed on daily oral omeprazole 20mg daily for a month by a pharmacist. She had been on the omeprazole medication for two weeks before her present symptoms manifested. Her past medical history was not suggestive of hypoparathyroidism nor pancreatitis. She was married with three children and has an uneventful family, social and obstetric histories. On examination, she was a healthy well-oriented young female with positive Trousseau’s, Chvostek’s and epigastric tenderness signs. Further Laboratory evaluation revealed she had low plasma magnesium, low plasma albumin-corrected calcium, and low serum parathyroid hormone levels, while other laboratory parameters were essentially normal. A diagnosis of omeprazole-induced electrolyte disorders (hypomagnesaemia and hypocalcaemia) associated with hypoparathyroidism was made following the review of her clinical examination and laboratory findings. She was subsequently managed with oral magnesium supplements following the withdrawal of the omeprazole medication (replaced with oral ranitidine), monitored weekly, and full recovery was achieved after three weeks.

Creators:	Collins Amadi Emmanuel M. Owamagbe Ugochukwu S. Duru
Updated:	23 September 2018 08:07:02
License:	Attribution-NonCommerical-ShareAlike
Download:	2475-9463-1-PB.pdf
Keywords:	Hypomagnesaemia, Hypocalcaemia, Hypoparathyroidism, Omeprazole

Resources for Medical Students and Professionals

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Dr. Bhaven Kataria
Department of Pharmacology,
GMERS Medical College, Sola
Ahmedabad, Gujarat, India

Creator:	Dr. Bhaven Kataria
Updated:	21 February 2015 11:55:25
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Download:	Resources for Medical Students and Professionals.pdf
Keywords:	Medical, Resources

MD pharmacology examination, question papers, Gujarat university, April 2013

Creators:	Dr. Pavan Panchal Dr. Bhaven Kataria
Updated:	13 April 2015 04:40:34
License:	Attribution-NonCommerical-ShareAlike
Download:	MD Pharmacology April 2013 GU.pdf
Keywords:	MD, Pharmacology, April 2013

MD pharmacology examination, question papers, Gujarat university, October 2012

Creators:	Dr. Pavan Panchal Dr. Bhaven Kataria
Updated:	13 April 2015 05:02:36
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Download:	October 2012 MD Pharmacology GU papers.pdf
Keyword:	October 2012

MD pharmacology examination, question papers, Gujarat university, April 2012

Creators:	Dr. Pavan Panchal Dr. Bhaven Kataria
Updated:	13 April 2015 04:58:09
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Download:	April 2012 MD Pharmacology GU papers.pdf
Keyword:	April 2012

Gujarat university, second MBBS examination, pharmacology question papers, January 2015

Creator:	Dr. Bhaven Kataria
Updated:	11 March 2015 11:05:58
License:	Attribution-NonCommerical-ShareAlike
Download:	Pharmacology paper I & II January 2015 Gujarat Uni.pdf
Keywords:	Pharmacology, January 2015, Question paper

Gujarat university, second MBBS examination, pharmacology question papers (2010-2014)

Creator:	Dr. Bhaven Kataria
Updated:	22 February 2015 03:25:59
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Download:	Pharmacology Papers Gujarat University (2010-2014).pdf
Keywords:	Pharmacology, 2010-2014, Question paper

Gujarat university, second MBBS examination, pathology question papers, January 2015

Creator:	Dr. Bhaven Kataria
Updated:	11 March 2015 11:19:34
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Download:	Pathology papers January 2015 Gujarat Uni.pdf
Keyword:	Pathology

Gujarat university, second MBBS examination, microbiology question papers, January 2015

Creator:	Dr. Bhaven Kataria
Updated:	11 March 2015 11:07:49
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Download:	Microbiology papers January 2015 Gujarat University.pdf
Keyword:	Microbiology

Gujarat university, second MBBS examination, forensic medicine question papers, January 2015

Creator:	Dr. Bhaven Kataria
Updated:	11 March 2015 11:02:28
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Download:	Forensic Medicine paper January 2015 Gujarat University.pdf
Keyword:	Forensic Medicine